Clinical Research
This is a listing of Loyola University Health System clinical research that is open and actively recruiting patients. Please click on the name of the research for a brief description, eligibility requirements and contact information. All research listed below have been approved by Loyola's Institutional Review Board chairman for promotion on our Web site.
For more information call (888) LUHS-888.
PSOLAR Registry Study for PsoriasisThe registry study will track the behavior of the disease in response to other therapies, such as adalimumab, alefacept, certolizumab pegol, efalizumab, etanercept and other biologics. The registry also will evaluate clinical outcomes, quality of life and potential risks for participants who may receive standard therapies for psoriasis.
Bladder Health
Nocturia StudyFemales patients with and without nocturia (waking for nighttime urination) both with and without diabetes or chronic kidney disease, will participate by completing questionnaires, a two-day urine diary, one blood sample, one fresh urine sample, and collect urine for 24 hours to assess kidney function.
The ABC TrialMany women experience the accidental loss of urine called urge incontinence or overactive bladder (OAB) incontinence. Women describe this as a sudden, strong desire to pass urine, which results in leakage before reaching the toilet. This study compares two groups of women who each receive both an active treatment for urge incontinence and a placebo (no active drug). Treatment group one will receive a single treatment with botulinum toxin A injection in the bladder and a six-month supply of placebo pills. Treatment group two will receive a single injection of saline in the bladder (placebo) and six months of active anticholinergic medication.
Value of Bladder TestsIt is common clinical practice to perform bladder tests, called urodynamic studies (UDS), before surgery for stress urinary incontinence (the accidental loss of urine with coughing, sneezing, laughing, exercise, or similar activities). Most doctors who regularly perform incontinence surgeries order these tests. We don’t know if women who receive these tests have better outcomes than women who don’t receive them. You are being asked to participate in a research study to determine if women who have demonstrated stress urinary incontinence (the accidental loss of urine with coughing, sneezing, laughing, exercise, or similar activities) during the office evaluation have different treatment outcomes compared to women who receive both the office evaluation and urodynamic studies before stress incontinence surgery.
Cancer
Assessment of Health Behaviors in Cancer SurvivorsTo assess the nutritional and health habits of cancer survivors.
GIDEONThe main purpose of this study is to determine the safety and effectiveness of sorafenib. How the health of participants develops while they are taking sorafenib also will be studied, as will participant satisfaction.
Treatment Therapy Followed by Umbilical Cord Stem Cell TransplantThe primary objective of this study is to measure progression free survival in the elderly at three years after umbilical cord stem cell transplantation, which may include an expanded umbilical cord stem cell unit and using pre-transplant conditioning of fludarabine, cyclophosphamide and total body irradiation.
Cancer: Brain
Chemotherapy and Radiation in Patients Newly Diagnosed With Brain CancerThe purpose of this study is to determine whether the addition of bevacizumab to the standard chemo-radiation will further improve the outcome. This study will find out what effects this change in treatment has on you and on your tumor compared with standard treatment.
Cancer: Breast
A Comparison of the Standard Treatment and an Experimental Treatment for Breast CancerThe purpose of this study is to evaluate which treatment is better for treating breast cancer.
Comparing Different Chemotherapy Regimens to Treat Breast Cancer Before Having SurgeryThe purpose of this study is to compare different chemotherapy treatments and determine which is better for breast cancer patients.
Comparing Different Regimens to Treat Breast Cancer Before SurgeryThe purpose of this study is to learn how breast cancer tumors respond to several different chemotherapy combinations.
Study Comparing Radiation Therapy With or Without Trastuzumab in Women With Early Stage Breast CancerThis purpose of this study is to find out if adding trastuzumab to breast radiation therapy is more effective than radiation therapy without trastuzumab in preventing occurrence of breast cancer in the same breast, in the other breast or in other parts of the body in patients with early stage breast cancer.
Cancer: Head and Neck
Chemotherapy in Patients With Recurrent Head and Neck CancerThe purpose of this study is to compare the effects (good and bad) of the addition of bevacizumab to standard chemotherapy (cisplatin and docetaxel or cisplatin and 5-FU) and to determine if the combination of standard chemotherapy and bevacizumab can increase the effectiveness of treatment for head and neck cancer. This combination is experimental.
Cancer: Leukemia
A Study Comparing the Addition of Midostaurin in the Treatment of Newly Diagnosed Patients Under 60 Years of Age With Acute Myeloid Leukemia (AML)The purpose of this study is to find out if adding midostaurin to cytarabine and daunorubicin is more effective in treating newly diagnosed acute myeloid leukemia patients under the age of 60.
Study Combining Azacitidine With Gemtuzumab Ozogamicin for Patients With Relapsed or Refractory Acute Myeloid LeukemiaThe purpose of this study is to see what effects, good and/or bad, the investigational drug combination of hydroxyurea, azacitidine and gemtuzumab ozogamicin has on acute myeloid leukemia.
Cancer: Lung
Chemotherapy in Individuals With Lung CancerThe primary objective of this study is:
In patients with advanced NSCLC treated with carboplatin, paclitaxel and bevacizumab (if appropriate) with or without cetuximab, to compare: a. Overall survival (OS) in the entire study population b. Progression-free survival (PFS) by institutional review in EGFR FISH-positive patients
The secondary objectives are:
In patients with advanced NSCLC treated with carboplatin, paclitaxel and bevacizumab (if appropriate) with or without cetuximab, to compare: a. OS and PFS by centralized review in EGFR FISH-positive patients b. PFS by centralized image review and by institutional review in the entire study population
To compare the response rate (confirmed plus unconfirmed, complete and partial responses) in the subset of patients with measurable disease in: a. EGFR FISH-positive patients b. The entire study population
The purpose of this study is to compare the effects, good and/or bad, of cetuximab on lung cancer.
Cancer: Lymphoma
Treatment Therapy Followed by Autologous Stem Cell TransplantThe primary objective of this study is to measure the level of busulfan chemotherapy and adjust the dose for each individual according to the level in the person’s blood during the preparative chemotherapies, followed by autologous hematopoietic stem cell transplant in people with Non-Hodgkin’s lymphoma and Hodgkin’s lymphoma.
Treatment of Patients With Relapsed or Refractory CD30-positive Disease While Completing EKG/ECG MonitoringThis study is being done to test if there are any changes in the ECG/EKG of cancer patients being treated with SGN-35 (brentuximab vedotin).
Cancer: Multiple Myeloma
A Study Investigating the Safety and Efficacy of Combining Three Chemotherapy Drugs as a Preparative Regimen for Multiple Myeloma Participants That Are Eligible for a Peripheral Blood Stem Cell TransplantThe purpose is to study the safety and efficiency of combining busulfan, melphalan and bortezomib as a preparative regimen for autologous hematopoietic stem cell transplant.
Cancer: Ovarian
Comparing Treatments for Ovarian Cancer That Has RelapsedThe purpose of this study is to compare different treatments for ovarian cancer that has relapsed.
Cancer: Ovary, Fallopian Tube, Primary Peritoneal
A Comparison of Different Chemotherapies and Routes of Administration for Ovarian, Fallopian Tube and Primary Peritoneal CancerThe purpose of this study is to determine which chemotherapy regimen is better for the treatment of ovarian, fallopian tube and primary peritoneal cancer.
Cancer: Pancreatic
Chemotherapy in Patients With Pancreatic Cancer That Has Spread to Other Parts of the BodyThe purpose of this study is to determine what effects the experimental drug GDC- 0449 has on your type of cancer.
Cancer: Renal/Kidney
Chemotherapy in Patients Who Have Cancer of the Kidney That Has Spread to Other Organs of the BodyThe purpose of this study is to compare the safety and effectiveness of the study drug Everolimus given before sunitinib versus sunitinib given before the study drug Everolimus, to determine the most effective order to give sunitinib and Everolimus to slow tumor growth and to determine which study treatment schedule has less side-effects.
Cancer: Uterus
Comparison of a Combination of Chemotherapy Drugs to the Standard Chemotherapy Treatment for Uterine CancerThe purpose of this study is to compare a different chemotherapy combination with the current standard chemotherapy treatment for uterine cancer.
Cancer: Bone
Bone Health in the Jaw of Cancer PatientsThe purpose of this study is to learn how often ONJ occurs in participants who cancer has spread to the bone and are being treated with zoledronic acid during a three-year time period after starting treatment. This study will also identify risk factors associated with ONJ.
Cancer: Brain
A Phase III trial comparing the standard dose of temozolomide with a more increased, longer lasting dose of temozlomide in patients with newly diagnosed glioblastomaThe purpose of this study is to determine whether increasing the duration of temozolomide treatment after radiation from five days out of 28 days (standard-dose schedule) to 21 days out of 28 days (dose-dense schedule) will further improve results.
Cancer: Breast
A randomized phase III study of whole breast radiation versus partial breast radiation for women with breast cancerThe purpose of this study is to see if partial breast irradiation is as good as or better than whole breast irradiation in keeping cancer from coming back in the breast.
Breast Cancer and Hormone Suppression StudyThe research is being done to determine if supressing ovary function during chemotherapy can reduce the incidence of premature menopause, which is often caused during adjuvant chemotherapy for breast cancer.
Breast Radiation Using Mammosite Brachytherapy (after breast conserving surgery)The purpose is to test whether radiation to part of the breast using brachytherapy after the removal of cancer gives similar results to those obtained when the whole breast receives radiation therapy. The study seeks to assess safety of the mammosite device in this setting, including the quality of life.
Comparing Different Treatments for Breast Cancer ParticipantsThis study will determine which treatment is better for certain breast cancer participants.
Medication Study for Hormone Receptor Positive Advanced Breast CancerThe purpose of this research is to study the effects (good and bad) of a new anti-cancer drug called lapatinib when added to an anti-estrogen drug called fulvestant for the treatment of advanced breast cancer.
Pathological Studies on Breast Cancer TissueThe purpose of the study is to analyze tumor specimens from breast cancer participants.
Preventing Neuropathy During Certain Breast Cancer Chemotherapy TreatmentsThe purpose of this study is to determine if the study drug prevents neuropathy of certain breast cancer chemotherapy treatments.
Recurrent Breast Cancer StudyThe purpose of this study is to determine how effective combining carboplatin, ABI-007 and bevacizumab are in the advanced breast cancer.
SOFT TrialThe purpose of this study is to see if shutting down a woman's ovaries plus giving tamoxifen is better at preventing the return of breast cancer than just giving tamoxifen alone in premenopausal women. It also will test whether a newer hormone drug called exemestane plus suppression of the ovaries is better than tamoxifen plus suppression of the ovaries. The side effects of these different treatments will be studied.
Study Between Lapatinib and Trastuzumab for Participants With Breast CancerThe main purpose of ALTTO is to find out whether lapatinib is effective in preventing cancer from returning and in extending survival in participants with HER2-positive breast cancer.
Study Using Two Investigational Drugs for Breast Cancer Participants Who Have Progressed While Receiving Prior TherapyTo determine how safe and tolerable the combination of the two investigational drugs are in certain breast cancer participants.
Treatment for Metastatic Breast Cancer with Anastrozole with or without FulvestrantThe purpose of this study is to determine how effective combining anastronzole with fulvestrant is compared to anastrozole alone in treating postmenopausal women with metastatic breast cancer.
Trial Comparing the Combinations of Medications Administered Prior to Breast Cancer SurgeryThe purpose of this study is to determine if combining two drugs, lapatinib and trastuzumab, with the chemotherapy drug paclitaxel before surgery increases tumor shrinkage in the breast.
Cancer: Cervical or Endometrial
Endometrial or Cervical Cancer Radiation Therapy StudyThe purpose of the study is to test whether the use of an advanced radiation therapy delivery technique called intensity-modulated radiation therapy (IMRT) can spare normal tissue, including small bowel and large bowel, from radiation. The research is being done to try to reduce radiation side effects (especially diarrhea) that occur with the standard radiation methods.
Cancer: Cervix
Comparing Certain Chemotherapy Treatments for Cervical CancerThe purpose of this study is to determine which chemotherapy treatment results in improved overall survival.
Cancer: Colorectal
Chemotherapy (either FOLFOX or FOLFIRI) in Combination With Avastin in Patients With Locally-advanced or Metastatic Colorectal CancerThis study is being done to evaluate if pegfilgrastim is needed to stop the white blood cells from decreasing too much during your cancer treatment and to evaluate the effect, if any, of pegfilgrastim on your progression-free and overall survival.
Cancer: Gallbladder or Bile Duct
Chemotherapy and Radiation for Participants With Cancer in the Bile Duct or GallbladderThe purpose of this study is to find out what effects, good and/or bad, capecitabine, gemcitabine and radiation have on you and your cancer of the bile duct or gallbladder.
Cancer: Kidney (Renal)
Measurement of Bone Strength to Help Predict Bone Fracture Risk While Taking SorafenibThe purpose of this study is to measure bone strength in order to help predict bone fracture risk while taking the study drug sorafenib and to learn whether sorafenib treatment has an effect on the heart pumping blood properly.
Cancer: Leukemia
A Study Evaluating the Safety and Efficacy of Combining Two Drugs for Participants Age 60 and Older on Previously Untreated Acute Myeloid LeukemiaThe purpose of this study is to find out the safety and efficacy of combining two drugs, azacitidine and gemtuzumab ozogamicin, to treat participants age 60 or older for untreated acute myeloid leukemia.
Leukemia Relapse TrialThe purpose of this study is to determine patient outcomes following high-dose combination chemotherapy treatment and to compare higher versus standard dose vincristine chemotherapy.
Cancer: Lung
Additional Chemotherapy Drug after surgical removal of Non Small Cell Lung CancerThe purpose of this study is to determine if adding the new drug bevacizumab to chemotherapy improves the chance for cure for patients who have had surgery for the removal of the lung cancer and to compare the effects (good and bad) of adding bevacizumab to chemotherapy compared to standard chemotherapy alone. Bevacizumab works by preventing the formation of new blood vessels, including those that surround and supply cancer cells, with the oxygen and nutrients they need to survive and grow.
Chemotherapy Agents in Patients With Lung Cancer That Has Grown Despite Earlier Treatment With ChemotherapyThe purpose of this study is to compare the effects, good and/or bad, of topotecan alone with topotecan plus AVE0005 to find out which is better. We would also like to find out more about the effects, good and/or bad, that weekly topotecan causes.
Lung Cancer Medication Study, with or without chemotherapy, after lung cancer surgeryThis study is testing to see if giving an oral medication (erlotinib) to early stage lung cancer patients who have had surgery to remove their tumors will keep the cancer from coming back. The tumors will be tested and must contain certain growth factors in order for you to participate in the study.
Medication Comparison for Women with Advanced Non-Small Cell Lung CancerThe investigational drug for this study (CT-2103) was designed to improve the delivery of the chemotherapy drug to tumor tissue while protecting normal tissue from toxic side effects. This study is designed to test whether CT-2103 with carboplatin can prolong life longer than paclitaxel with carboplatin.
Mineral Therapy After Lung Cancer SurgeryThis research is being done to study whether taking selenium (a mineral) can prevent the development of second lung cancers.
Radiation Therapy in Patients With Lung Cancer That Has Spread to Other Parts of the Body.The purpose of this study is to:
• Find out if radiation therapy improves the survival of patients with your type of cancer, when given after chemotherapy. • Find out what effects (good and bad) that radiation therapy after standard chemotherapy has on you and your cancer.
Cancer: Lymphoma
A Study to Investigate the Effects of SGN-35 on Your Heart Rate and Heart RhythmThe purpose of this study to investigate the effects of SGN-35 on your heart rhythm.
Chemotherapy Treatments for Diffuse Large B-cell Lymphoma.The purpose of this study is to compare the effects (good and bad) of two treatments for lymphoma. The treatments are known as R-CHOP and DA-EPOCH-R. Another goal of the study is to analyze your tumor using new scientific laboratory studies to better understand your type of lymphoma.
Chemotherapy for Relapsed/Refractory Non-Hodgkin's Lymphoma.The purpose of this study is to compare galiximab given with rituximab or with rituximab alone to determine what effects (good or bad) galiximab has on you, and to determine how galiximab and rituximab are broken down by your body.
Evaluation of Treatments for Newly Diagnosed Burkitt’s and Burkitt-like LymphomaThe primary objective of this study is to evaluate the effects of two different chemotherapy treatment regimens in patients with Burkitt’s and Burkitt-like lymphoma
Evaluation of Cisplatin Plus Etoposide Plus Gemcitabine Plus Solumedrol (PEGS) in Peripheral T-Cell Non-Hodgkin’s LymphomaThe purpose of this study is to find out what effects (good and bad) the combination of cisplatin, etoposide, gemcitabine, and solumdrol (PEGS) has on you and your lymphoma.
Medication Study for Relapsed Hodgkins LymphomaThis study is for people with relapsed or refractory Hodgkins lymphoma. The purpose is to see what effects (good and bad) a drug called temsirolimus has on you and your lymphoma.
Treatment Therapy Followed by Stem Cell Transplant for Relapsed Follicular Non-Hodgkin’s LymphomaThe primary objective of this study is to measure progression-free survival at two years after allogeneic hematopoietic stem cell transplantation (HSCT) using pre-transplant conditioning of fludarabine, cyclophosphamide and rituximab (FCR) for patients with relapsed follicular non-Hodgkin’s lymphoma.
Treatment for Participants with Advanced Follicular Non-Hodgkin’s LymphomaThe purpose of the study is to evaluate your response (good and bad) of receiving R-CHOP and tositumomab followed by maintenance treatment for participants with follicular non-Hodgkin lymphoma.
Treatment of Aggressive Hodgkin Lymphoma Based on PET Scan ResultsThis study will follow PET scan results to determine if your disease is responding to standard treatment for your Hodgkin lymphoma. If it is not responding, you will be switched to a more intensive treatment plan.
Treatment of Relapsed Mantle Cell Non-Hodgkin’s Lymphoma With LenalidomideThe purpose of this study is to see what effects (good and bad) a drug called lenalidomide has on you and your lymphoma.
Treatment of relapsed or refractory ALCLThis study is being done to test if SGN-35 (treatment drug) has an effect on cancer in patients with ALCL.
Cancer: Prostate
A Study Evaluating Early Treatment With Zoledronic Acid for Men With Prostate CancerThe purpose of this study is to determine if early treatment with zoledronic acid delays bone problems for men with prostate cancer involving the bone.
Cancer: Rectal
A Combination of Chemotherapy (Including Cetuximab), Radiation Therapy and Surgery for Participants With Stage II or III Rectal CancerThe purpose of this study is to find out what effects, good and/or bad, the combination of the chemotherapies, radiation therapy and surgery has on the participant and their rectal cancer.
Cancer: Skin (Melanoma)
Vaccine Trial for Melanoma Patients Whose Disease Has Metastasized (Stage IV).The main purpose of the study is to determine the safety of the trial's experimental procedure and the maximum dose of the vaccine that a human can tolerate. A secondary purpose is to see if the experimental procedure causes the melanoma cancer to shrink.
Cancer: Soft Tissue Sarcoma
Chemotherapy Study for Sarcoma PatientsThis study will determine the benefit of an investigational drug (AVE8062), which is an antivascular treatment that works by destroying the small vessels that feed the tumor with blood, for patients with soft-tissue sarcoma whose treatments with anthracycline and ifosfamide have failed.
Cancer: Uterine
Study Comparing Standard Radiation Therapy Treatment to an Investigational Treatment of Radiation Therapy Combined with Chemotherapy in Patients with Endometrial (Uterine) CancerThe purpose of this study is to determine if the study treatment is more effective than the standard treatment of uterine cancer.
Cancer:Gastric and gastroesophageal junction (GEJ)
Chemotherapy in Patients With Advanced Stomach CancerThe purpose of this study is to find out what effects GDC-0449 in combination with FOLFOX chemotherapy has on you and your gastroesophageal adenocarcinoma cancer.
Cardiovadiovascular Health: Arrhythmia
Multidisciplinary Study of Right Ventricular Dysplasia (ARVD)This is a multidisciplinary, multicenter collaborative study to investigate the cardiac, clinical and genetic aspects of arrhythmogenic right ventricular dysplasia (ARVD). The primary goal is to identify 100 patients with definite ARVD and their family members. The study offers a substantial prospect of expanding the fund of clinical knowledge regarding ARVD and/or localizing the genetic mutation(s) responsible for this disorder.
Cardiovascular
SELECT-AFThe purpose of this study is to compare two different computer strategies to identify abnormal signals in the atrium for ablation that are not around the pulmonary veins.
Cardiovascular Health
CABANA TrialAtrial fibrillation is an abnormal, rapid heart rhythm coming from the upper chambers of the heart (atria). Atrial fibrillation is the most common type of heart rhythm disorder. Instead of the heart beating in a steady pattern, in atrial fibrillation the upper chambers of the heart quiver rapidly in an unsteady manner. Atrial fibrillation may be treated with drug therapy designed to either prevent the heart rate from going too fast, or with drug therapy designed to maintain normal heart beating. In some institutions, atrial fibrillation also is treated with catheters inserted into blood vessels that can be placed inside the heart to eliminate the hot spots or triggers that start atrial fibrillation (catheter ablation). It is not known whether drug therapy or catheter ablation is better.
The Catheter Ablation Versus Anti-arrhythmic Drug Therapy for Atrial Fibrillation (CABANA) study is being done to compare drug therapy and catheter ablation in patients with atrial fibrillation. This study will help decide which treatment approach is best or when one or the other therapy is preferred. The CABANA study also will compare the cost of care for the two treatment approaches and determine the effect these therapies have on quality of life.
Cardiovascular Health: Atherosclerosis
TIMI-50 Atherosclerosis StudyThe purpose is to evaluate patients with blockages in one or more arteries supplying blood to the heart, brain or legs. The study will evaluate if the study drug blocks platelet build-up which can cause blockage.
Cardiovascular Health: Diabetes
FREEDOM TrialThe purpose of this study is to compare two different methods of treatment for patients with diabetes mellitus and coronary artery disease in more than one heart vessel. The study seeks to evaluate whether drug-eluding stenting is more or less effective than coronary artery bypass surgery (CABG).
Cardiovascular Health: Heart Failure
Double-Blind, Placebo-Controlled, Multicenter Acute Study of Clinical Effectiveness of Nesiritede in Subjects with Decompensated Heart Failure (ASCEND-HF)This study is being done to find out if the drug that is being researched, nesiritide (tradename Natrecor®)? as compared to placebo (pill with an inactive substance which looks like the real drug), plus the usual treatment for acute decompensated heart failure (standard of care) helps:· improve your breathing difficulties· reduce the chance that you will be readmitted to the hospital· patients live longer
Cardiovascular: Marfan Syndrome
Aortic Valve Surgery in Marfan PatientsThe purpose of the trial is to collect information on how patients do after having surgery on their aortic valve and compare the results of those who had their valve replaced to those who had the valve repaired.
Cardiovascular: Peripheral Vascular Disease
Lower Limb Ischemia StudyThe purpose of this clinical research is to determine if bone marrow cells that are harvested from your bone and then grown in a lab, or expanded, can be used as a method for treatment of critical limb ischemia in patients with peripheral artery disease.
Endocrinology: Diabetes
Diabetes Type 2 and Exenatide Observational StudyThe purpose of this study is to collect information on how a medication called exenatide is being used to treat patients with type 2 diabetes and how well it works on improving blood sugar control.
The Sunshine StudyThe purpose of this study is to determine whether taking vitamin D supplementation will help with control of blood sugar and with improving mood.
Endocrinology: Growth Hormone
Growth Hormone Deficiency StudyThe purpose of the study is to compare long-term health outcomes in patients who are lacking adult growth hormones.
Health volunteers
Primary Care Patients’ Attitudes, Views and Decision-making About a New Type of Genetic Testing Available Directly to Consumers Through the InternetThe purpose of this research is to learn about primary care patients’ views, attitudes and decision-making considerations regarding a new type of genetic testing available through the internet. The first stage involves discussion groups to explore these questions. The second stage involves offering some participants this new type of genetic testing and interviewing them at three different times.
Heart Disease: Atrial Fibrillation
ARISTOTLE: Apixaban for Reduction In STroke and Other ThromboemboLic Events in Atrial FibrillationAtrial fibrillation is a common arrhythmia of the heart that puts you at risk for stroke. To reduce the risk, anticoagulant medication is used to reduce the formation of blood clots. This study is testing an oral investigational drug. The purpose of the study is to compare the safety and effectiveness of the investigational drug to warfarin in preventing stroke or clots in patients with atrial fibrillation and risk factors for stroke.
Mental Health: Depression
Endothelial Function in Depressed PatientsThe purpose of this study is to determine whether depressed individuals show signs of dysfunction in their blood vessels.
Quetiapine May Lower Cardiovascular Risk Due to Depression and AnxietyThe purpose of this study is to determine if quetiapine can reverse the arterial stiffening that often occurs in depression and anxiety, which are believed to be risk factors for future heart disease.
Arterial stiffness will be measured non-invasively by a procedure called applanation tonometry. The measures serve as markers of subclinical hardening of the arteries and may be able to show a response to therapy, if such hardening is present. The procedure involves positioning of a probe on the skin overlaying certain arteries in the body, namely the radial, carotid and femoral. Heart rate variability similarly is determined non-invasively by placing three leads on the chest and determining heart function. Treatment with quetiapine may restore normal heart function.
Neurosciences
Quetiapine May Lower Cardiovascular Risk Due to Depression and AnxietyTo determine if quetiapine treatment of depression and anxiety can reverse the arterial stiffening that often occurs in depression and anxiety, which are believed to be risk factors for future heart disease.
Skin Health: Psoriasis
ESPIRIT registry study for psoriasisThe purpose of this registry is to observe the degree of long-term safety of adalimumab and how well it works to treat chronic plaque psoriasis for up to 10 years. Adalimumab is a marketed drug for psoriasis. No medication is provided for this registry. Your doctor will give you a prescription for adalimumab.
Etanercept Psoriasis RegistryThe purpose of this study is to continue to gather and evaluate information on the long-term safety of etanercept in a large number of patients with plaque psoriasis.
PSOLAR registry study for psoriasisThe registry study will track the behavior of the disease in response to other therapies, such as adalimumab, alefacept, certolizumab pegol, efalizumab, etanercept, and other biologics. The registry will also evaluate clinical outcomes, quality of life, and potential risks for patients who may receive standard therapies for psoriasis
Stroke
ALIAS - Albumin in acute strokeMany stroke studies have been performed looking for an effective treatment for patients who have suffered an acute ischemic stroke. Thus far, all have failed. This study seeks to determine the effectiveness of albumin versus placebo given intravaenously for stroke patients.
IRIS: Insulin Resistance Intervention After Stroke TrialBoth stroke and heart attack are serious medical problems. The purpose of this study is to see if stroke and heart attack can be reduced in insulin resistant non-diabetic adults using an approved drug versus a placebo (inactive drug).
Neck artery blockageCarotid artery occlusion can be a dangerous factor for TIA and stroke. The study will look at the outcome after brain artery/vein bypass surgery versus best medical therapy.
The Experience of Female Caregivers of Stroke SurvivorsThe purpose of this study is to describe how female caregivers of stroke survivors cope with the stress of care-giving.
Transplant: Lung
Investigational Medication to Help Prevent Rejection after Lung TransplantationThe purpose of this research study is to assess whether or not inhaled cyclosporine (CIS), in addition to other medications that suppress the immune system, will help to prevent the new lung(s) from being rejected by the body’s natural defense system.
Lung Transplant: Does Cyclosporine Inhaled Solution Help Prevent the Rejection?The purpose of this study is to determine whether inhaled cyclosporine (CIS), in addition to other medications that put down the immune system, helps prevent a new lung(s) transplant from being rejected by the body’s natural defense system.
Women's Health: Prolapse and Bladder Control
The OPTIMAL TrialThe OPTIMAL study has two purposes: 1) compare two standard vaginal surgical techniques; and 2) see if patients do better when they receive pelvic muscle exercises and behavioral instructions around the time of surgery.